Computational and systems medicine

The development of personalized health care strategies is to understand how genetic alterations or chemical perturbations that individually have only a modest contribution to disease risk or treatment response may lead to strong synergistic effects on disease progression, treatment efficacy or toxicity when combined. While such epistatic and synthetic lethal interactions play a role in many diseases including cardio metabolic diseases and cancer treatment, their systematic identification has remained difficult because of complex networks underlying genotype-phenotype relationships.

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